The efficacy and safety of ultrafiltration for patients with heart failure: results from a single-center randomized controlled study
10.3760/cma.j.issn.0253-3758.2017.07.010
- VernacularTitle: 心力衰竭专用超滤设备治疗心力衰竭有效性和安全性的随机对照研究
- Author:
Xiangli SHEN
1
;
Libiya ZU
;
Lan LI
;
Jun MA
;
Baojian ZHANG
;
Shubin JIANG
Author Information
1. Heart Center of Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi 830000, China
- Publication Type:Clinical Trail
- Keywords:
Heart failure;
Ultrafiltration;
Treatment outcome
- From:
Chinese Journal of Cardiology
2017;45(7):608-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of ultrafiltration in patients with heart failure.
Methods:One hundred and thirty four cases of patients with heart failure, who hospitalized in our hospital from June 2010 to June 2016 were enrolled in this study. Random serial number was generated using SPSS 22.0 software, patients were then randomly divided into control group and ultrafiltration group with the proportion of 1∶1 (67 cases in each group). Patients in the control group received standard therapy. Patients in the ultrafiltration group received ultrafiltration therapy for 8 hours. Curative effect was evaluated after 8 hours treatment in the control group and after 12 hours in the ultrafiltration group. Following parameters were compared between the two groups: body weight, dyspnea score and 6 minutes walking distance as well as blood pressure, heart rate, Na+ , K+ , Cl-, pH, HCO3-, Hb, PLT, Cr, BUN levels.
Results:(1)Two patients died during run-in process and eventually 132 cases were chosen for final analysis (65 cases in control group and 67 cases in the ultrafiltration group). Gender, age, type of heart failure, dyspnea score, body weight at baseline were similar between the two groups. (2)Post therapy, patients′ body weight decreased obviously, while dyspnea score and 6 minutes walking distance increased significantly in the ultrafiltration group compared to baseline(all P<0.05), and the improvement was significantly greater compared to control group(all P<0.05). (3)The safety index comparison of two groups: blood pressure, heart rate, Na+ , K+ , Cl-, pH, HCO3-, Hb, PLT, Cr, and BUN were similar between the two groups at baseline and post therapy.
Conclusion:Ultrafiltration therapy is safe and effective to treat patients with heart failure.
