The clinical study on the correlation of lysophosphatidic acid and vascular endotheli growth factor and endothelin in serum of pneumoconiosis
10.3760/cma.j.issn.1001-9391.2017.07.008
- VernacularTitle: 尘肺患者血清溶血磷脂酸及血管内皮生长因子和内皮素水平的临床研究
- Author:
Lijun MAO
1
;
Yanlin ZHANG
;
Cuicui CONG
;
Li GUAN
;
Shuqiang LI
;
Jinyuan ZHAO
Author Information
1. Mao Lijun and Zhang Yanlin contributed equally to the article. Research Center of Occupational Medicine, Peking University Third Hospital, Beijing 100191, China
- Publication Type:Case Reports
- Keywords:
Pneumoconiosis;
Lysophospholipids;
Vascular endothelial growth factor;
Endothelin;
Pulmonary fibrosis
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(7):508-510
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of lysophosphatidic acid, vascular endothelial growth facor and endothelin in the pathogenesis of pulmonary fibrosis in coal workers’pneumoconiosis patients, the relationship of lysophosphatidic acid, VEGF and ET in serum was studied.
Methods:Sixty two pneumoconiosis patients were selected as cases group, which included 23 cases of stage Ⅰ, 25 cases of stageⅡand 14 cases of stageⅢ. Twenty workers were selected as dust exposure group who exposed to coal dust for more than 2 years and had not been diagnosed as pneumoconiosis. Ten healthy people who had no occupational dust exposure were simultaneously selected as the control group. The serum levels of LPA, VEGF and ET were measured by ELISA.
Results:The serum levels of VEGF and ET in coal dust exposed group and pneumoconiosis group were much higher than in the control group. The differences were statistically significant among the three groups (P<0.01) . The serum levels of LPA increased in the dust exposed group, stage Ⅰand stage Ⅱgroup. The serum levels of LPA correlated positively with the levels of VEGF and ET (P<0.05) .
Conclusions:The serum levels of LPA, VEGF and ET had evident correlation with the pulmonary fibrosis caused by coal dust, which indicate that LPA, VEGF and ET may play a pivotal role in the process of pulmonary fibrosis. The study will throw light on both pathogenesis and early intervention for pneumoconiosis.
