Clinical characteristics and prognosis of anaplastic thyroid carcinoma
10.3760/cma.j.issn.0253-3766.2017.06.007
- VernacularTitle: 56例甲状腺未分化癌的临床特点和预后分析
- Author:
Jiafeng WANG
1
;
Xuhang ZHU
2
;
Zhuo TAN
1
;
Minghua GE
1
Author Information
1. Department of Head and Neck Surgery, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
2. Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310022, China
- Publication Type:Clinical Trail
- Keywords:
Thyroid neoplasms;
Anaplastic thyroid carcinoma;
Prognosis;
Therapy
- From:
Chinese Journal of Oncology
2017;39(6):434-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics, treatment outcomes and prognostic factors in patients with anaplastic thyroid cancer.
Methods:Clinical data of 56 patients with anaplastic thyroid cancer at Zhejiang Cancer Hospital from January 2006 to June 2016 were retrospectively reviewed and followed up.
Results:Of the 56 patients, there were 24 male and 32 female. The median age was 65 years old. At diagnosis, 10 patients have different degrees of breathing difficulty; 8 patients have varying degrees of dysphagia, and 12 patients have hoarseness. Distant metastases were found in 23 patients at presentation. Patient staging was performed in accordance with the tumor-node-metastasis system as follows: stage ⅣA (n=19), stage ⅣB (n=14) and stage ⅣC (n=23). The median survival time of 56 patients was 4.5 months.The overall 1-year survival rate was 5.4%. Univariate analysis showed that radiotherapy and multimodality therapy were prognostic factors for 1-year overall survival (both of P<0.05). The overall 1-year survival rate of the patients who received precision radiotherapy was 16.7%, which was higher than who received the other radiation therapy (4.0%, P=0.040). Furthermore, the overall 1-year survival rate of the patients who received surgery combined with radiotherapy was 12.5%, which was higher than who received the other treatments(4.2%, P=0.040). Multivariate analysis indicated that radiotherapy was independently associated with improved survival (P=0.020).
Conclusions:Patients with anaplastic thyroid cancer should receive multimodality therapies combining surgery with radiotherapy. Radiotherapy is independently associated with improved overall survival. Notably, the precision radiotherapy that based on image guidance has a significantly beneficial impact on the prognosis of patients.
