RET/PTC rearrangement affects multifocal formation of papillary thyroid carcinoma
10.3760/cma.j.issn.1673-0860.2017.06.008
- VernacularTitle: RET/PTC基因重排对甲状腺乳头状癌多灶性形成的影响
- Author:
Xing ZHANG
1
;
Xuan SU
1
;
Weichao CHEN
1
;
Yin LI
1
;
Zhongyuan YANG
1
;
Wenze DENG
1
;
Tiancheng DENG
1
;
Ankui YANG
1
Author Information
1. Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Carcinoma, papillary;
RET/ PTCrearrangement;
Multifocal tumor
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2017;52(6):435-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective:RET/PTC gene rearrangement can lead to aberrant activation of tyrosine kinase receptors, which is a common mutation in papillary thyroid carcinoma (PTC). This study focuses on the association of RET/PTC rearrangements with PTC clinical factors.
Methods:From January 2011 to December 2013, a total of 114 patients with PTC were enrolled in this study. Clinicopathological parameters, lifestyle, and thyroid hormone levels were collected. RET/PTC rearrangements were detected by TaqMan PCR and verified by Sanger sequencing.Data were analyzed with SPSS software, including chi-square test, Fisher′s exact test, Mann-Whitney U test, Student′s t-test, and Logistic regression.
Results:RET/PTC rearrangements were not found in all paracancerous normal thyroid tissues, and were detected in 23.68% (27/114) of PTC. Further analysis revealed no correlation between RET/PTC rearrangement and thyroid function, clinicopathologic parameters, and lifestyle in the total PTC group or in the subgroup of patients with concomitant diseases (including Hashimoto′s thyroiditis and nodular goiter). But in the subgroup of PTC without concomitant disease, RET/PTC rearrangement was associated with tumor multifocal (P=0.018), and RET/PTC-positive PTC patients had an increased risk of tumor multifocal (OR=5.57, 95% CI 1.39-22.33). It was also found that RET/PTC rearrangement was associated with an abnormal increase in TSH level of one month after surgery (P= 0.037).
Conclusion:Nodular goiter and Hashimoto ′s thyroiditis may be a confounding factor in PTC. RET/PTC rearrangement may play an important role in the occurrence of thyroid carcinoma multifocal after exclusion of this confounding factor.
