Preliminary evaluation of reducing residual risk of blood transfusion-transmitted infection by using HBV DNA detection
10.3760/cma.j.issn.1003-9279.2017.06.012
- VernacularTitle: 乙型肝炎病毒核酸检测降低输血感染残余风险的初步评估
- Author:
Zhanjuan YU
1
;
Yuexia WANG
2
;
Hao LYU
2
;
Xiangyang LI
1
Author Information
1. Wenzhou Medical College, Wenzhou 325035, China
2. Quzhou Blood Center, Quzhou 324000, China
- Publication Type:Journal Article
- Keywords:
NAT;
HBV;
Residual risk of transfusion;
Blood transfusion safety
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(6):534-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the reduction of the residual risk of blood transfusion- transmitted hepatitis B virus (HBV), using nucleic acid detection(NAT)test for enzyme linked immunosorbent assay (ELISA) qualified volunteer-donor bloods in Quzhou area after NAT was developed.
Methods:Specimens were collected from March 2016 to March 2017, detected by ELISA twice with two different reagents and NAT only once. The residual risks of blood transfusion-transmitted HBV infection were calculated by mathematical model of risk evaluation.
Results:Totally 27 646 specimens were collected from March 2016 to March 2017, which included 76 specimens that were both ELISA and NAT positive, 31 specimens were ELISA negative but NAT positive.The total number of NAT positive specimens was 107.The residual risk of HBV by ELISA test was 28.2×10 -5and NAT test was 13.0×10-5.
Conclusions:NAT detection can greatly reduce the residual risk of blood transfusion-transmitted HBV infection, and provide effective value for bloods safety in practice.
