Expression and role of SOCS-3 and associated cytokines in HIV/TB coinfection
10.3760/cma.j.issn.1003-9279.2017.06.007
- VernacularTitle: SOCS3及相关细胞因子在HIV/TB双重感染者血清中表达水平的研究
- Author:
Fang ZHAO
1
;
Xiaoning LIU
;
Lin CHENG
;
Liumei XU
;
Shaxi LI
;
Kanru CAI
;
Yun HE
;
Hui WANG
;
Yingxia LIU
Author Information
1. Shenzhen Third People’s Hospital, Shenzhen, 518112, China
- Publication Type:Journal Article
- Keywords:
Aequired immunodeficiency syndromes;
Mycobacterium tuberculosis;
HIV/TB;
SOCS3;
Cytokines
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(6):515-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression levels and clinical significance of serum suppressor of cytokine signaling-3 (SOCS3) and associated cytokines in HIV/TB co-infected patients.
Methods:The serum levels of SOCS3, IFN-γ, IL-2, IL-4, IL-6, IL-10, IL-17 and IL-22 were quantified by using enzyme-linked immunosorbent assays (ELISA) in 50 HIV-infected patients, 48 HIV/TB co-infected patients and 50 healthy donors. Pearson correlation analysis was used to analyze the correlation between SOCS3 and other seven cytokines.
Results:Serum levels of SOCS3 expression in HIV/TB co-infection group were significantly higher than those in HIV-infection alone and the control group. There was also significant correlation between SOCS3 and IFN-γ, IL-4, IL-6, IL-10, IL-2 in HIV/TB co-infection group.
Conclusions:These findings indicated that SOCS3 may play an important role in the immune response of patients with HIV/TB co-infection and it may be helpful in the diagnosis of HIV/TB co-infection.
