The progression of tumor liquid biopsy and its applications in precision medicine
10.3760/cma.j.issn.0529-5815.2017.06.001
- VernacularTitle: 肿瘤液体活检的进展及其在精准医疗中的应用
- Author:
Shaohua ZHANG
1
;
Yi LIU
;
Bing LIU
;
Zefei JIANG
Author Information
1. Center of Cancer, Academy of Military Medical Sciences, Beijing 100071, China
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Biopsy;
DNA, neoplasm;
Neoplastic cells, circulating;
Extracellular vesicles
- From:
Chinese Journal of Surgery
2017;55(6):401-405
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor is the most heterogeneous human disease, and it has been gradually reached the consensus in clinical oncology that the personalized treatment of tumor patients should be directed by molecular diagnostics. However, the ever-changing characteristic of tumor in heterogeneity and the fact that tissue samples are usually unavailable highlight the function and significant of liquid biopsy. The material that could be used in liquid biopsy are mainly the circulating tumor DNA, circulating tumor cells and extracellular vesicles, which though have their own advantages and disadvantages, but could complement to each other, thus accurately and comprehensively reflecting the characteristic of the tumor and gave the best direction for patient′s individualized therapy. This article reviewed the recent advances of liquid biopsy and explained its importance in tumor precision medicine.
