Diagnostic value of serum cystatin C for acute kidney injury in patients with liver cirrhosis
10.3760/cma.j.issn.1007-3418.2017.05.010
- VernacularTitle: 血清胱抑素C对肝硬化患者并发急性肾损伤的诊断价值
- Author:
Junjun CAI
1
;
Jing ZHOU
;
Tao HAN
;
Yuling ZHANG
;
Huaiping LIU
;
Yanchao FU
Author Information
1. Department of Hepatology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Artificial Cell, Tianjin Institute of Hepatobiliary Disease, Tianjin 300170, China
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Hepatorenal syndrome;
Kidney tubular necrosis, acute;
Diagnosis;
Acute tubular necrosis
- From:
Chinese Journal of Hepatology
2017;25(5):360-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the diagnostic value of serum cystatin C (Cys C) for acute kidney injury (AKI) in patients with liver cirrhosis.
Methods:Serum Cys C levels in 150 liver cirrhosis patients (88 AKI and 62 non-AKI patients) were measured by the Particle-Enhanced Nephelometric Immuno-Assay. The accuracy of serum Cys C for the diagnosis of AKI in liver cirrhosis was evaluated by the ROC curve.
Results:Liver cirrhosis patients with AKI had significantly higher serum Cys C levels [2.37 (1.75-2.83) mg/L] than those without AKI [0.97 (0.85-1.09) g/L] (P <0.001). Serum Cys C level was highest in the acute tubular necrosis group [5.41 (2.77-6.19) mg/L], followed by the hepatorenal syndrome group [2.55 (2.28-3.59) mg/L] and prerenal azotemia group [2.07 (1.70-2.41) mg/L], and the serum Cys C level was significantly different between the three groups (P <0.001). In addition, patients with AKI were further divided into infection group and non-infection group. Serum Cys C level was significantly higher in the infection group than in the non-infection group (P <0.05). The area under the ROC curve of serum Cys C for the diagnosis of AKI in liver cirrhosis was 0.99 (0.98-1.00) at a cut-off value of 1.36 mg/L, and the sensitivity and specificity were 97% and 95%, respectively.
Conclusion:Serum Cys C is a good marker for detecting AKI in liver cirrhosis, and the different levels of increase in Cys C may be useful in differentiating the different types of AKI.
