Molecular markers for the monitoring of malignant transformation of hepatocytes and early diagnosis of liver cancer
10.3760/cma.j.issn.1007-3418.2017.05.002
- VernacularTitle: 分子标志物监测肝细胞恶性转化及肝癌早期诊断
- Author:
Yan YANG
1
;
Min YAO
2
;
Miao FANG
2
;
Wenjie ZHENG
3
;
Zhizhen DONG
3
;
Dengfu YAO
3
Author Information
1. The Wuxi People’s Hospital, Wuxi 214023, China
2. Medical School of Nantong University, Nantong 226001, China
3. Affiliated Hospital of Nantong University, Nantong 226001, China
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Diagnosis;
Molecular marker;
Malignant transformation;
Monitoring
- From:
Chinese Journal of Hepatology
2017;25(5):325-328
- CountryChina
- Language:Chinese
-
Abstract:
The monitoring of malignant transformation of hepatocytes or early diagnosis of primary hepatocellular carcinoma (PHC) remains a challenge in the medical world. Routine examinations including serum alpha-fetoprotein level and ultrasound examination have a limited value in the diagnosis of small hepatocellular carcinoma; however, the effective treatment of PHC depends on its early diagnosis. In recent years, molecular markers including important signaling molecules in PHC-related pathways, carcinoembryonic proteins, and non-coding RNA help with the monitoring of malignant transformation of hepatocytes or early diagnosis of liver cancer. This article reviews the valuable molecular markers in the monitoring of malignant transformation of hepatocytes or early diagnosis of liver cancer.
