Clinicopathologic characteristics of plasma cell myeloma with marrow fibrosis
10.3760/cma.j.issn.0529-5807.2017.05.009
- VernacularTitle: 伴骨髓纤维化的浆细胞骨髓瘤临床病理学分析
- Author:
Huilan LI
1
;
Kun RU
;
Qi SUN
;
Zhanqi LI
;
Hongju ZHANG
;
Yue MA
;
Mu XIAN
;
Lugui QIU
;
Enbin LIU
Author Information
1. Department of Pathology, Department of Lymphoma & Myeloma, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union of Medical College, Tianjin 300020, China
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
In situ hybridization, fluorescence;
Flow cytometry
- From:
Chinese Journal of Pathology
2017;46(5):327-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinicopathologic features of plasma cell myeloma(PCM) with bone marrow fibrosis (MF).
Methods:The clinicopathologic data of 175 cases of newly diagnosed PCM patients were retrospectively analyzed. Based on reticular fiber staining, these cases were divided into PCM-MF and non-PCM-MF groups.
Results:Sixty-three cases were PCM-MF(36%), 112 were non-PCM-MF (64%). No statistical difference in gender, age, hemoglobin level, platelet counts, the classification of immunoglobulin, ISS staging, immunohistochemical phenotypes and genetic features was found between PCM-MF and non-PCM-MF groups (P>0.05). Compared to non-PCM-MF group, lactate dehydrogenase (LDH)level and renal impairmentrate were higher in PCM-MF group (P<0.05). The degree of bone marrow hyperplasia, the percentage of myeloma cells and cells with plasmablastic morphology were significantly higher in PCM-MF group(P<0.05).
Conclusion:The higher LDH level, renal impairment rate, and more significant bone marrow hyperplasia, proliferation of plasma cells and plasmablastic myeloma cells infiltration indicate poor prognosis of PCM-MF patients.
