Advances in the research of role of integrin-linked kinase in angiogenesis

VernacularTitle: 整合素连接激酶在血管生成中的作用研究进展
Author: Wangbiao ZHOU ¹ ; Yeyang LI
Author Information

1. Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Ji′nan University, Guangzhou 510220, China
Publication Type:Review
Keywords: Neovascularization, physiologic; Neovascularization, pathologic; Integrin-linked kinase; Mechanism
From: Chinese Journal of Burns 2017;33(5):317-320
CountryChina
Language:Chinese
Abstract: Integrin-linked kinase (ILK) has been found for twenty years, and its biological characteristics have been extensively studied by multi-discipline. At present, studies of ILK are mainly focused on its roles in angiogenesis, tumor formation, and tissue fibrosis, etc. In recent years, the regulation effect of ILK in angiogenesis attracts attention of researchers. The studies showed that ILK can stimulate the secretion of angiogenic factor, promote the proliferation and migration of endothelial cells and inhibit their apoptosis, and therefore play an important role in the regulation of angiogenesis. Further research on molecular mechanism about the role of ILK playing in angiogenesis may provide an effective method for the treatment of some diseases.