Analysis of the biomechanical property and histocompatibility of acellular porcine fascia
10.3760/cma.j.issn.1009-4598.2017.05.011
- VernacularTitle: 脱细胞猪阔筋膜的生物力学性能及生物相容性分析
- Author:
Qi SONG
1
;
Kai ZHANG
;
Juan TANG
;
Kejie CAI
;
Yonghua ZHAI
;
Kunpeng PANG
;
Xuejiao QIN
Author Information
1. Qilu Hospital of Shandong University, Department of Operating Theatre, Jinan 250012, China
- Publication Type:Journal Article
- Keywords:
Fascia lata;
Extracellular matrix;
Swine;
Biomechanics;
Histocompatibility
- From:
Chinese Journal of Plastic Surgery
2017;33(5):373-378
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the biomechanical property and histocompatibility of acellular porcine fascia so as to supply a new substitute material for tissue repair.
Methods:Samples of normal porcine fascia, acellular porcine fascia and normal human fascia were prepared for histological and biomechanical examination. Xenogeneic fresh porcine fascia, acellular porcine fascia and allogeneic rabbit fascia were implanted into the back of rabbit. Tissues were taken for HE staining and histocompatibility test.
Results:Histological examination showed that the cellular components which elicit immune rejections had been removed in the acellular porcine fasciam, with the complete extracellular matrix reserved. Arrangement of collagen fiber was loose in the acellular porcine fascia. The biomechanical performance test of the three samples showed that there was no significant difference in the extreme tensile strength (4.47±0.54) MPa, (4.49±0.91) MPa, (4.79±1.35) MPa for acellular porcine fascia, normal porcine fascia and normal human fascia respecively, P>0.05). There was no significant difference between acellular porcine fascia extracellular matrix and porcine fascia with the cell in breaking elongation (501.83%±52.01%, 661.17%±200.28%, P>0.05). However, there was a significant difference in the breaking elongation between human fascia (98.08%±26.02%)and the other 2 kinds of porcine fascia (P<0.01). Histocompatibility test showed the local reactions of the acellular porcine fascia group were weaker than the normal porcine fascia group.
Conclusions:With sound preparativemethod, the acellular porcine fascia has good biomechanical property and histocompatibility and may serve as a good alternative material for tissue repair.
