Clinical analysis of 112 patients with HIV/AIDS complicated with smear negative pulmonary tuberculosis
10.3760/cma.j.issn.1003-9279.2017.05.016
- VernacularTitle: HIV/AIDS合并痰抗酸菌涂片阴性肺结核112例临床分析
- Author:
Xiaoying WU
1
;
Yunhao XUN
;
Tiefeng LYU
;
Jianhua YU
;
Daiqiang SHI
Author Information
1. Xixi Hospital of Hangzhou, Hangzhou 310023, China
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Acquired immune deficiency syndrome;
Pulmonary tuberculosis
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(5):450-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features and reliable diagnostic method in HIV/AIDS patients with smear negative pulmonary tuberculosis (TB).
Methods:Clinical data of 112 HIV/AIDS patients complicated with smear negative pulmonary TB who were treated in our hospital from January 2013 to September 2015 were retrospectively analyzed. These clinical data includeded clinical symptom, blood routine test, blood biochemistry, T lymphocyte subsets classification, sputum acid-fast bacillus smear, mycobacterium tuberculosis culture, purified protein derivatives tuberculin (PPD) test, interferon gamma-release assay for Mycobacterium tuberculosis (T-SPOT.TB), TB-DNA and chest computed tomography (CT). Diagnostic specificity and sensitivity of these parameters were analyzed.
Results:No specific clinical manifestation of these patients was identified. The chest CT feature was also atypical. The positive rates including T-SPOT, TB, TB-DNA and PPD test were all low. The positive rates of T-SPOT.TB and PPD test in patients with a CD4+ cell count >200 cells/μl was significantly higher than that of patients with a CD4+ cell count ≤50 cells/μl and 51≤CD4≤200 cells/μl (P<0.01).
Conclusions:The clinical feature of smear negative pulmonary TB in HIV/AIDS patients is atypical. For a definite diagnosis, a comprehensive analysis with clinical manifestations, laboratory test, imaging examination and etiologic detection is required.
