Protectivity of hepatitis B surface antibody in children between 1 and 3 years after successful blocking of mother-to-child transmission
10.3760/cma.j.issn.1003-9279.2017.05.005
- VernacularTitle: 母婴阻断成功儿童1岁至3岁乙肝表面抗体的保护性研究
- Author:
Weihua CAO
1
,
2
;
Ying ZHNAG
1
;
Minghui LI
3
;
Chongping RAN
3
;
Tianlin QI
3
;
Xingyue WANG
3
;
Yuhong HU
4
;
Mingshu ZHOU
4
;
Lu ZHANG
3
;
Yao LU
3
;
Shuling WU
3
;
Ge SHEN
3
;
Hongxiao HAO
3
;
Min CHANG
3
;
Leiping HU
3
;
Ruyu LIU
3
;
Wenhao HUA
5
;
Wei YI
4
;
Yao XIE
1
Author Information
1. Department of Liver Diseases Center, Beijing Ditan Hospital, Peking University Teaching Hospital, Beijing 100015, China
2. Liver Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
3. Liver Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
4. Department of Obstetrics and Gynecology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
5. Clinical Test Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Hepatitis B surface antibody;
Hepatitis B vaccine;
Mother-to-child transmission
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(5):401-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the change of hepatitis B surface antibody (HBsAb) titer and its long-term protection and infection rates between 1 and 3-year-old children whose mothers were chronic hepatitis B pregnant woman with HBeAg positive and high viral load after successful blocking of mother-to-child transmission.
Methods:One-year-old children whose mothers were hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive, with HBV DNA≥106IU/ml were enrolled, then were followed up till 3 years old, and tested the five serological markers of hepatitis B and biochemical parameters at the age of one and three years respectively, and analyzed HBsAb titer, positive rate, negative rate and infection rate of 1 to 3-year-old children without enhanced vaccination; meanwhile, data of HBsAb titers at the age of 7 months were collected HBsAb titer, positive rate, and negative rate were analyzed.
Results:Totally 264 1-year-old children were enrolled into the study, including 178 children without enhanced vaccination between seven months and 1 year of age, and 114 children without enhanced vaccination between 1 year and 3 years of age. Our result showed that there were no infected children at the age between 1 and 3 years. HBsAb titer decreased from 7 months to 1 year old and dropped from 1 000 IU/L to 509.43 IU/L (P<0.05), and the antibody was still protective. From 1 year to 3 years old, HBsAb titer dropped from 466.72 IU/L to 67.3 IU/L (P< 0.05); at the age of 3 years, 60.52 % children were either weakly positive or negative, but still protective, but significantly less than those who had the reinforced vaccination. As a result , the children without the enhanced vaccination between 1 and 3 years of age were still at high risk.
Conclusions:If the antibody was protective at 7 months, children were not easily infected between 1 year and 3 years of age. At the age of 3, the antibody dropped to low or no responsive levels, and the children were still at high risk. It is necessary to take protective measures and supplement the vaccine.
