Association of single nucleotide polymorphism of IL-6 gene with susceptibility to hepatitis B virus
10.3760/cma.j.issn.1003-9279.2017.05.004
- VernacularTitle: IL-6基因单核苷酸多态性与中国汉族人群乙型肝炎易感性的相关性研究
- Author:
Xiuyun ZHU
1
;
Wenfei WANG
;
Weigang WU
;
Hongchun LI
;
Weilong LIU
;
Mingxia ZHANG
;
Lei LIU
Author Information
1. Third People’s Hospital of Shenzhen, Guangdong Key Laboratory for Diagnosis & Treatment of Emerging Infectious Diseases. Shenzhen (518112) China
- Publication Type:Journal Article
- Keywords:
Single nucleotide polymorphism;
Interleukin-6;
Hepatitis B virus
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(5):397-400
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Leukocyte mediated IL-6 (IL-6) plays an important role in chronic viral hepatitis pathogenesis and related liver diseases, We did a large sample-size case-control study and clinical data analysis to find association between IL-6 single nucleotide polymorphism and HBV susceptibility, and to achieve the detection of the body on the expression of IL-6 for the prevention and treatment of HBV infection.
Methods:Totally 848 HBV patients and 894 healthy controls in Shenzhen were selected and rs1800796 genotypes were determined by TaqMan assays.
Results:The result showed that rs1800796 polymorphism was associated with susceptibility to HBV infection (P=0.0003, odds ratio (OR)=1.43, the difference was statistically significant.
Conclusions:The single nucleotide polymorphism of IL-6rs1800796 locus was associated with the susceptibility of HBV infection in Chinese population, and the rs1800796 G allele is a protective gene for HBV infection.
