Value of early-stage cerebral oxygen utilization coefficient in predicting delayed encephalopathy after acute carbon monoxide poisoning
10.3760/cma.j.issn.1001-9391.2017.05.006
- VernacularTitle: 早期脑氧利用率对一氧化碳中毒迟发性脑病的预测
- Author:
Qian LIU
1
;
Wei LI
;
Na LI
;
Qingmian XIAO
;
Jiaqi HE
;
Weizhan WANG
;
Hongna QI
;
Pu WANG
Author Information
1. Department of Emergency, Harrison International Peace Hospital Affiliated to Hebei Medical University, Hengshui 053000, China
- Publication Type:Case Reports
- Keywords:
Carbon monoxide poisoning;
Delayed encephalopathy after acute carbon monoxide;
Poisoning oxygen utilization coefficient;
Forecasting
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(5):348-350
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the dynamic change in cerebral oxygen utilization coefficient (O2UCc) in the early stage of acute severe carbon monoxide poisoning (ASCMP) and its value in predicting delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) .
Methods:A prospective observational study was conducted for patients with ASCMP who were admitted to our hospital from November 2013 to March 2016, and their baseline features and physiological parameters were recorded. Observation ended at two months after acute poisoning; according to the presence or absence of DEACMP, the patients were divided into DEACMP group with 21 patients and non-DEACMP group with 64 patients. The change in O2UCc was monitored on admission and at 6, 24, 48, and 72 hours. Spearman correlation was used to investigate the correlation between O2UCc and Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and the receiver operating characteristic (ROC) curve was used to evaluate the accuracy of O2UCc in predicting DEACMP.
Results:Both groups had a significant increase in O2UCc on admission, and the DEACMP group had a significantly greater increase than the non-DEACMP group (52.57%±9.30% vs 41.46±%6.37%, P<0.05) . Then both groups tended to have a reduction in O2UCc, and the DEACMP group had a significantly higher O2UCc than the non-DEACMP group at 6, 24, and 48 hours (47.40%±7.92%, 39.38%±8.01%, and 32.29%±6.31% vs 34.51%±7.89%, 28.79%±5.4%, and 27.72%±5.46%, P<0.05) . On admission and at 6, 24, and 48 hours, O2UCc was positively correlated with APACHE II score (r=0.304, 0.398, 0.426, and 0.300, P=0.005, 0.000, 0.000, and 0.005) . The ROC curve showed that O2UCc had a value in predicting DEACMP on admission and at 6, 24, and 48 hours, and 6-hour O2UCc had the highest predictive value with an area under the ROC curve of 0.870 (95% confidence interval 0.794-0.947, P<0.05) .
Conclusion:The dynamic change in O2UCc has a reference value in early identification of DEACMP, and O2UCc can be used as an important reference index for predicting DEACMP.
