The correlation study of ground glass opacity and lepidic growth pattern component in stage I lung invasive adenocarcinoma
10.3760/cma.j.issn.0253-3766.2017.04.006
- VernacularTitle: Ⅰ期浸润性肺腺癌磨玻璃成分定量分析及其与附壁样生长成分的相关性研究
- Author:
Li ZHANG
1
;
Ning WU
1
;
Meng LI
1
;
Wei SUN
2
;
Lü LYU
1
;
Donghui HOU
1
;
Dongmei LIN
2
Author Information
1. Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2. Department of Pathology, Beijing Cancer Hospital, Beijing 100036, China
- Publication Type:Clinical Trail
- Keywords:
Lung neoplasms;
Adenocarcinoma;
Ground Glass Opacity;
Tomography, X-ray computed;
Pathology
- From:
Chinese Journal of Oncology
2017;39(4):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between Ground Glass Opacity (GGO) component proportion and quantitative classification of lepidic growth pattern in pathological stage Ⅰpulmonary adenocarcinoma.
Methods:Pathological and HRCT data of 183 stage Ⅰ invasive adenocarcinoma patients from January 2005 to December 2012 were retrospectively reviewed. The proportion of GGO was calculated from diameter and volume.The correlation between GGO component proportion and lepidic growth pattern in pathological were analyzed by Spearman correlation.
Results:Among 183 patients, the proportion of GGO component calculated by maximum diameter method and three-dimensional computerized quantification was 0.43±0.35 and 0.20±0.18, respectively. The percentage of lepidic growth pattern component using semi-quantitative analysis of pathological sections was 0.29±0.25.The proportion of GGO by diameter and three-dimensional computerized quantification was significantly correlated with the percentage of lepidic growth pattern component (r=0.599, P< 0.001; r=0.620, P<0.001).
Conclusions:There was a positive correlation between the content of lepidic growth pattern and the content of GGO in the small adenocarcinoma. Three-dimensional computerized quantification was a better method in preoperational evaluation.
