Clinicopathologic features of drug-induced vanishing bile duct syndrome
10.3760/cma.j.issn.1007-3418.2017.04.019
- VernacularTitle: 药物相关性胆管消失综合征的临床病理特征
- Author:
Lihong YE
1
;
Chongkui WANG
2
;
Haicong ZHANG
1
;
Zhiquan LIU
1
;
Huanwei ZHENG
3
Author Information
1. Department of Pathology, Shijiazhuang Fifth Hospital, Shijiazhuang 050021, China
2. Heibei University of Chinese Traditional Medicine, Shijiazhuang 050200, China
3. Hepatology center, Shijiazhuang Fifth Hospital, Shijiazhuang 050021, China
- Publication Type:Review
- Keywords:
Pathology, clinical;
Vanishing bile duct syndrome;
Drug induced;
Prognosis;
Pathogenetic mechanism
- From:
Chinese Journal of Hepatology
2017;25(4):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Vanishing bile duct syndrome (VBDS) manifests as progressive destruction and disappearance of the intrahepatic bile duct caused by various factors and cholestasis. VBDS associated with drug-induced liver injury (D-VBDS) is an important etiology of VBDS, and immune disorder or immune imbalance may be the main pathogenesis. According to its clinical symptoms, serological markers, and course of the disease, D-VBDS is classified into major form and minor form, and its clinical features are based on various pathomorphological findings. Its prognosis is associated various factors including regeneration of bile duct cells, number of bile duct injuries, level and range of bile duct injury, bile duct proliferation, and compensatory shunt of bile duct branches. This disease has various clinical outcomes; most patients have good prognosis after drug withdrawal, and some patients may experience cholestatic cirrhosis, liver failure, and even death. Due to the clinical manifestation and biochemical changes are similar to the primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), it need to identify by clinical physician.
