Expression and significance of STAT6 in solitary fibrous tumor
10.3760/cma.j.issn.0529-5807.2017.04.004
- VernacularTitle: 信号转导及转录激活因子6在孤立性纤维性肿瘤中的表达和意义
- Author:
Zhiyan DING
1
;
Yanfen WANG
;
Xuan WANG
;
Qiu RAO
Author Information
1. Department of Pathology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
- Publication Type:Journal Article
- Keywords:
Solitary fibrous tumors;
STAT6 transcription factor;
Immunohistochemistry;
Diagnosis, differential
- From:
Chinese Journal of Pathology
2017;46(4):235-239
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinicopathologic features, the differential diagnosis and the expression of STAT6 in solitary fibrous tumor (SFT).
Methods:Eighty cases of SFT were evaluated. The expression of STAT6, CD34, CD99 and bcl-2 protein was studied in these cases and in other groups of soft tissue tumors by immunohistochemical EnVision method. The results were analyzed and relevant literature were reviewed.
Results:The expression rate of STAT6 in SFT was 97.5% (78/80) and that in other soft tissue tumors was 3.3% (3/90). The difference was significant (P<0.05). The expression rates of CD34, CD99 and bcl-2 were 88.8% (71/80), 76.3% (61/80) and 75.0% (60/80) in SFT, respectively, which were significantly different from STAT6 expression rate (P<0.05).
Conclusions:The expression of STAT6 in SFT has high sensitivity (97.5%) and specificity (96.7%). The expression of STAT6 in SFT is higher than that of CD34, CD99 and bcl-2. STAT6 may be a useful marker for clinical diagnosis of SFT.
