Retrospective analysis of penciclovir combined with foscarnet sodium in the treatment of herpes zoster
10.3760/cma.j.issn.1003-9279.2017.04.012
- VernacularTitle: 喷昔洛韦联合膦甲酸钠治疗带状疱疹的回顾性分析
- Author:
Jie KONG
1
;
Yuanjun LIU
;
Manli QI
;
Yuqing QI
;
Yan LI
;
Shuping HOU
;
Xin ZHENG
;
Suju LUO
;
Lili SHAO
;
Jing WANG
;
Huiping WANG
;
Quanzhong LIU
Author Information
1. Department of Dermatology and Venereology, Tianjin Medical University General Hospital, Tianjin 300052, China
- Publication Type:Journal Article
- Keywords:
Herpes zoster;
Neuralgia;
Penciclovir;
Foscarnet sodium
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(4):329-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the therapeutic efficacy of penciclovir combined with foscarnet sodium in the treatment of herpes zoster.
Methods:The clinical datas of 135 herpes zoster patients from the ward of Department of Dermatology, Tianjin Medical University General Hospital were collected. Among them 64 patients received penciclovir and foscarnet sodium, and the remaining 71 patients only received penciclovir alone.Their general information, the time for vesicle stopped emerging, rash began to scab, pain to relief obviously, the adverse reaction and if they got the postherpetic neuralgia were recorded and included into statistical analysis.
Results:The general information showed no significant differences between the 2 groups(all P>0.05). The time for vesicle stopped emerging, rash began to scab, pain to relief obviously in combination group was shorter than the penciclovir group (all P<0.001). The number of patients who developed postherpetic neuralgia of combination group was fewer than that of penciclovir group(P=0.013). There was no statistical significance between the 2 groups the adverse reaction(P=0.928).
Conclusions:The penciclovir and foscarnet sodium combination therapy showed rapid therapeutic effects on herpes zoster patients, the incidence of postherpetic neuralgia was low, and there was no more side effects than penciclovir alone therapy. The combined therapy may be a reliable way to treat herpes zoster.
