Risk evaluation of high-risk human papillomavirus genotyping in cervical lesions progress
10.3760/cma.j.issn.1003-9279.2017.04.006
- VernacularTitle: 高危型人乳头状瘤病毒感染在宫颈病变进展中的风险研究
- Author:
Huihui XU
1
;
Haiyan ZHU
2
;
Tongtong ZHANG
3
;
Xianwen SHANG
4
;
Jiazheng YU
4
;
Weihua YAN
1
Author Information
1. Medical Research Center, Wenzhou Medical University Affiliated to Taizhou Hospital of Zhejiang Province, Linhai 317000, China
2. Clinical Laboratory, Wenzhou Medical University Affiliated to Taizhou Hospital of Zhejiang Province, Linhai 317000, China
3. Health Management Center, Wenzhou Medical University Affiliated to Taizhou Hospital of Zhejiang Province, Linhai 317000, China
4. Department of Gynecology, Wenzhou Medical University Affiliated to Taizhou Hospital of Zhejiang Province, Linhai 317000, China
- Publication Type:Journal Article
- Keywords:
Human Papillomavirus;
Genotype;
Screening;
Precancerous Conditions
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(4):302-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical value of high-risk humam papillomavirus(HR-HPV) genotyping in diagnosis of cervical lesions.
Methods:Between December 2012 and March 2015, a total of 4 095 women who were diagnosed as cervical inflammation-related disease were chosen to be evaluated in gynecological clinic at Taizhou Hospital of Zhejiang Province. All the women experienced HPV genotyping, analysis of the epidemiological characteristics of HPV types in Taizhou area and theresult of histopathologic diagnosis of HPV positive women. Logistic regression analysis was used to estimate the risk of HR-HPV genotyping in cervical lesion progression.
Results:Overall, HPV52 was the most prevalent genotype, followed by HPV16, 58, 39 and 56. Among the women with cervical intraepithelial neoplasm (CIN), HPV16 was the most frequent type, followed by HPV52, 58, 33 and 31. Logistic regression analysis showed that a higher risk of CIN2+ for women infected with HPV16 or HPV33, the regression coefficients OR were 3.670(95%CI: 2.399-5.612, P<0.05) and 2.045(95%CI: 1.087-3.848, P<0.05), respectively. Logistic regression analysis showed that a higher risk of CIN2+ for NILM with positive HPV16, and the regression coefficients OR were 2.539(95%CI: 1.622-3.976, P=0.000); the ASCUS with positive HPV16 and 58 had higher risk of CIN2+ , the regression coefficients OR were 1.911(95%CI: 0.530-6.893) and 1.757(95%CI: 0.557-5.548), respectively.
Conclusions:HPV genotyping has important clinical value to detect precancerous cervical lesions, especially when cervical cytology is negative, in management of patiemts with atypical squamous cells of an undertermined significance(ASCUS) or low grade squamous intraepithelial lesion(LSIL).
