Role of Nitric oxide and endothelial nitric oxide synthase in infants with cytomegalovirus hepatitis
10.3760/cma.j.issn.1003-9279.2017.04.004
- VernacularTitle: 婴儿巨细胞病毒性肝炎患儿体内一氧化氮和内皮型一氧化氮合酶水平的研究
- Author:
Xiaofeng LI
1
;
Xia LIN
2
;
Huiqin CHEN
1
;
Yun CAI
1
;
Pingping ZHANG
1
;
Zhuanggui CHEN
1
Author Information
1. Department of Pediatrics the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
2. Department of Obstetrics the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
- Publication Type:Journal Article
- Keywords:
Cytomegalovirus;
Hepacivirs;
Nitric oxide;
Endothelial nitric oxide synthase;
Child, hospitalized
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(4):295-297
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the potential clinical role of nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) in infants suffering from infantile cytomegalovirus hepatitis (ICH).
Methods:NO and eNOS were measured in 56 ICH infants and 50 healthy controls by using ELISAmethod .
Results:NO and eNOS were significantly increased in ICH group as compared with the controls (P<0.01) accompanied by increased ALT in infants of ICH group (P<0.05). Both of NO and eNOS levels were significantly positively correlated with the level of ALT(r=0.682, r=0.746, P<0.05). However, neither NO level nor eNOS level was significantly correlated with the number of copies of HCMV-DNA (r=-0.087, r=-0.134, P>0.05).
Conclusions:The expressions of NO and eNOS were significantly increased in infants with human cytomegalovirus hepatitis, and were closely related to the severity of liver lesion.
