Molecular characteristics of the untranslated segment-specific region of the hemagglutinin segments in H5N6 and H7N9 influenza viruses in Shenzhen
10.3760/cma.j.issn.1003-9279.2017.04.003
- VernacularTitle: 深圳市H5N6、H7N9流感病毒HA-UTR基因分子特征分析
- Author:
Yanci CHEN
1
;
Xin WANG
2
;
Bo PENG
2
;
Weihua WU
2
;
Hui LIU
2
;
Yijie GENG
2
;
Qing ZHENG
1
;
Shisong FANG
2
Author Information
1. College of Pharmacy, Jinan University, Guangzhou 510632, China
2. Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China
- Publication Type:Journal Article
- Keywords:
H5N6 influenza virus;
H7N9 influenza virus;
Hemagglutinin(HA);
Untranslated region;
Homology;
Polymorphism
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(4):291-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Exploring the molecular characteristic of global and Shenzhen district H5N6 and H7N9 influenza viruses HA untranslated regions(UTRs).
Methods:Mega7.0 and DNAStar 7.1.0 were used to construct phylogenetic tree and nucleotide analysis.
Results:From 2014 to 2015, 3 strains of H5N6 influenza virus from Shenzhen were compared with the other H5NX influenza viruses, the nucleotide homology of HA-3’UTR was 77.4%-100%, which did not have obvious mutated sites. The nucleotide homology of H5N6-HA-5’UTR was 91.7%-100%, and the sites of 24 and 31 sites were mutated. From 2013 to 2014, 11 strains of H7N9 influenza virus from Shenzhen were compared with the other H7NX influenza viruses, the nucleotide homology of H7N9-HA-5’UTR was 76.8%-100%, which had multi-mutated sites on 2-6, 9, 10, 12 and 15-17 positions.
Conclusions:HA-UTR from human-infected H5N6 and H7N9 influenza viruses isolated in Shenzhen district has unique molecular characteristics, its conserved region has relatively high homology and the segment-specific region has genetic polymorphism.
