Recombinant human tumor necrosis factor receptor type Ⅱ-IgG Fc fusion protein for treatment of occupational medicamentosa-like dermatitis induced by trichloroethylene
10.3760/cma.j.issn.1001-9391.2017.04.004
- VernacularTitle: 重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白治疗重症职业性三氯乙烯药疹样皮炎的疗效
- Author:
Lingling LV
1
;
Zhihua YAN
;
Xin SHI
;
Runqiu LIU
;
Xin LING
;
Sunping JI
;
Jing ZHANG
;
Ping LI
;
Yonglian CAI
;
Lingling CHEN
;
Xiaojian CHEN
;
Lixia XIE
;
Dandan LU
;
Lan DING
;
Qianqian XU
;
Yun ZHANG
;
Xiaowen YANG
;
Jing JING
;
Li YING
;
Cuiping YU
;
Jingjing CHEN
;
Xiaodong SUN
Author Information
1. Dermatology Department of Second Affiliated Hospital of Soochow University, Suzhou 215004, China
- Publication Type:Journal Article
- Keywords:
Trichloroethylene;
Dermatitis, occupational;
Receptors, tumor necrosis factor
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(4):257-260
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of the recombinant human tumor necrosis factor receptor Ⅱ-IgG Fc fusion protein (rhTNFR: Fc, etanercept) for the treatment of occupational medicamentosa-like dermatitis induced by trichloroethylene (OMLDT) .
Methods:In September 2011 to February 2016, 12 patients with OMLDT were treated with etanercept 25 mg, subcutaneous injection, twice per week, doubling of first dose. The course of treatment was 6 weeks. The drug eruption area and severity index (DASI) score, the proportion of patients achieving a 50%, 75% and 90% reduction in DASI (DASI50, DASI75, DASI90) and the serum level of TNF-α were used to assess the efficacy at different times. Adverse reactions were also recorded and evaluated. The results were statistically analyzed by nonparametric Friedman test and repetitive measurement ANOVA using the software SPSS19.0.
Results:After 4 weeks treatment, the DASI score decreased form 56.33±7.02 to 0.50±0.91 (P<0.01) . The DASI50, DASI75 and DASI90 were all increased to 12 (100%) . The serum level of TNF-α decreased form (43.74±41.62) pg/ml to (3.03±0.47) pg/ml (P<0.01) . Statistically significant difference was observed from the above indexes. There were no adverse reactions in clinical application.
Conclusion:Recombinant human tumor necrosis factor receptor Ⅱ-IgG Fc fusion protein may be a safe and effective drug in the treatment of OMLDT.
