Pilot study on the functional evaluation of vestibular otolith-organ pathway in the stage of patients with Meniere disease
10.3760/cma.j.issn.1673-0860.2017.03.006
- VernacularTitle: 前庭耳石器通路功能评价在梅尼埃病分期中的初步研究
- Author:
Xiaorong NIU
1
;
Peng HAN
2
;
Zichen CHEN
2
;
Yuzhong ZHANG
2
;
Ying GAO
2
;
Ying CHENG
2
;
Juan HU
2
;
Yong XU
3
;
Qing ZHANG
2
;
Min XU
2
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710061, China
2. Department of Otorhinolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
3. Department of Otorhinolaryngology, Xi′an 141 hospital, Xi′an 710089, China
- Publication Type:Journal Article
- Keywords:
Meniere disease;
Vestibular evoked myogenic potentials;
Saccule and utricle
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2017;52(3):195-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the features of air-conducted sound elicited ocular vestibular-evoked myogenic potential(ACS-oVEMP) and cervical vestibular-evoked myogenic potential(ACS-cVEMP) in patients with Meniere disease (MD). To analyze the relationship between air-conducted sound elicited vestibular-evoked myogenic potentials (ACS-VEMP) responses and clinical stages of disease, as well as its clinical application of cervical and ocular vestibular evoked myogenic potentials in MD.
Method:Fifty six patients with MD and 50 normal subjects (100 ears) were recruited for conventional cVEMP and oVEMP examinations. Grades of vestibular function were also collected for patients with MD. The relationship between VEMPs abnormity, grades of vestibular function and clinical stages of MD were analyzed.
Results:The abnormal rates of cVEMP and oVEMP in MD patients were 57.1% (32/56) and 64.3% (36/56), which were significantly higher than those in normal subjects respectively (χ2=22.286, P=0.000; χ2=15.217, P=0.000). The abnormal rates of cVEMP and oVEMP in MD patients of stage Ⅰ to stage Ⅳ were 20.0% (1/5) and 40.0% (2/5), 50.0% (9/18) and 50.0% (9/18), 59.3% (16/27) and 70.4% (19/27), and 100.0% (6/6) and 100.0% (6/6) respectively. There was a significant difference in cVEMP abnormity between four stages of MD patients (P=0.046). Significant correlation was found between clinical stages and the grades of vestibular dysfunction (rs=0.417, P=0.001).
Conclusions:Dysfunction of vestibular otolithic organs and their input pathways in patients with MD can be detected by cVEMP and oVEMP tests. The abnormal rates of VEMP could show an gradually increasing trend with the development of MD stages. And the extent of vestibular lesions could be detected by cVEMP and oVEMP tests, which may provide a reference for clinical staging of MD.
