Advances in effects of integrin-linked kinase on cutaneous wound healing and the relative mechanism

VernacularTitle: 整合素连接激酶在皮肤创面愈合中的作用及其相关机制研究进展
Author: Rixing ZHOU ¹ ; Yeyang LI ; Weihua LIN ; Gang LI ; Jing′en SUN ; Wangbiao ZHOU
Author Information

1. Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Ji′nan University, Guangzhou 510220, China
Publication Type:Review
Keywords: Skin; Wounds and injuries; Wound healing; Integrin-linked kinase; Mechanism
From: Chinese Journal of Burns 2017;33(3):190-192
CountryChina
Language:Chinese
Abstract: Previous studies have demonstrated that integrin-linked kinases (ILKs) are abundantly expressed in extracellular matrix (ECM) riche dermis, hair follicles, and basal cells of epidermis. ILKs are not only essential for the maintenance of skin structure, but also play important roles in wound healing. ILKs can promote the formation of granulation tissue by stimulating the proliferation of fibroblasts and secretion of ECM, accelerate wound contraction by inducing the differentiation of fibroblasts to myofibroblasts, and boost reepithelization by promoting proliferation, migration, and differentiation of keratinocytes and follicle epidermal stem cells.