Advances in the research of basic study and clinical application of adipose-derived mesenchymal stem cells

VernacularTitle: 脂肪源性间充质干细胞的基础与临床应用研究进展
Author: Shengjun CAO ¹ ; Lingfeng WANG ; Te BA ; Zhidong RONG ; GuoLin HU ; Biao ZHOU ; Quan LI
Author Information

1. Department of Burns, the Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China
Publication Type:Review
Keywords: Stem cells; Adipose derived stem cells; Basic research; Clinical application
From: Chinese Journal of Burns 2017;33(3):184-189
CountryChina
Language:Chinese
Abstract: Since the discovery of adipose-derived mesenchymal stem cell (ADSC) in more than ten years, a great progress has been made from its basic research to clinical application. Compared with bone marrow mesenchymal stem cells, ADSCs are more abundant in reserve, easier to obtain with fewer injuries and less complications. These cells have multiple differentiation potential and can differentiate into adipocytes, chondrocytes and osteoblasts with the influence of different inducing factors. Early studies of ADSCs mainly focused on the ability of multi-directional differentiation, espe-cially on the regeneration of bone defects and cartilage tissue. At present, the researches mainly focus on immunoregulation and paracrine function of ADSCs. Although ADSCs have made a great progress in clinical application, the cell preparation, use pattern, and mechanisms in clinical treatment are not clear. This paper elaborates on these issues.