Research progress in innate immune mechanisms during influenza A virus infection

VernacularTitle: 甲型流感病毒天然免疫机制研究进展
Author: Xinfa WANG ¹ ; Yingxia LIU
Author Information

1. Department of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen 518112, China
Publication Type:Review
Keywords: Influenza A virus; Innate immunity; Pattern recognition receptor
From: Chinese Journal of Experimental and Clinical Virology 2017;31(3):277-280
CountryChina
Language:Chinese
Abstract: Influenza A virus is an enveloped virus of the Orthomyxoviridae family. Acute fever, generalized pain, fatigue and respiratory symptoms are the typical symptoms after influenza A virus infection. Influenza A virus triggers the activation of signaling pathways that are dependent on host pattern recognition receptors (PRRs) including toll-like receptors (TLRs), retinoic acid-inducible gene I receptors (RLRs) and NLRs. Then these signaling pathways activate downstream transcript factors that induce expression of various interferons and cytokines (IL-1, IL-18). This review will elaborate the mechanisms of these PRRs.