Clinical analysis of 978 children with influenza
10.3760/cma.j.issn.1003-9279.2017.03.005
- VernacularTitle: 978例儿童流感临床分析
- Author:
Yunjuan LI
1
;
Lei WANG
2
;
Yang WANG
3
;
Yaoli SUN
4
;
Qiaomian YIN
1
;
Yan WANG
1
Author Information
1. Department of Pediatric Internal Medicine, Beijing New Century International Children’s Hospital, Beijing 100045, China
2. PICU, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China
3. Heart Center, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China
4. Department of Infection Control, Beijing New Century International Children’s Hospital, Beijing 100045, China
- Publication Type:Journal Article
- Keywords:
Influenza;
Children;
Epidemiology;
Clinical features;
Drug therapy
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(3):202-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical features and treatment of children with influenza, and provide evidence for clinical screening and appropriate treatment timely.
Methods:Epidemiology, clinical manifestations, laboratory features and drug therapy of 978 pediatric patients with influenza in Beijing New Century International Children's Hospital in 2014 were analyzed retrospectively.
Results:Among the 978 pediatric patients with influenza, 90.8%were outpatients, while 9.92% were inpatients. The incidence was the highest in winter (85.28%). The age of most cases ranged from 1 to 5 years (57.16%). The cases with type A influenza accounted for 81.29%. High fever (99.59%) and cough (85.89%) were the two main symptoms. The average count of WBC was 6.86±2.68×109/L, lymphocyte percentage was lower than the proportion of neutrophils. CRP was normal (66.16%) or slightly-increased (19.00± 15.12 mg/l). Compared with type A influenza, digestive tract symptoms were more common in cases with type B (P=0.000). Analysis of 97 hospitalized cases: the main diagnosis was lower respiratory tract infection (71.13%). Nearly 23.71% cases had been detected to have combined infection with other pathogenic agents. Course of fever in cases who started taking oseltamivir after fever of 48 hours was significantly longer than those who took within 48 hours (P=0.000). Seven severe pneumonia cases were mainly in young children, cases with underlying disease or mixed infection, they were all cured by active and comprehensive therapy.
Conclusions:Influenza in children is characterized by high fever and cough, digestive tract symptoms frequently occurred in patients with type B influenza. Early application of oseltamivir could signficantly shorten the period of fever. Severe cases should be given active and comprehensive treatments.
