Serum Chitotriosidase Activity in Pulmonary Tuberculosis: Response to Treatment and Correlations with Clinical Parameters.
10.3343/alm.2012.32.3.184
- Author:
Gulhan CAKIR
1
;
Seyfettin GUMUS
;
Ergun UCAR
;
Hatice KAYA
;
Ergun TOZKOPARAN
;
Emin Ozgur AKGUL
;
Bulent KARAMAN
;
Omer DENIZ
;
Ismail KURT
;
Metin OZKAN
;
Hayati BILGIC
Author Information
1. Department of Pulmonary Medicine, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey.
- Publication Type:Original Article
- Keywords:
Chitotriosidase;
Tuberculosis;
Lung
- MeSH:
Adult;
Antitubercular Agents/therapeutic use;
Biological Markers/blood;
Fluorometry;
Hexosaminidases/*blood;
Humans;
Male;
ROC Curve;
Severity of Illness Index;
Tuberculosis, Pulmonary/drug therapy/*enzymology/radiography;
Young Adult
- From:Annals of Laboratory Medicine
2012;32(3):184-189
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Chitotriosidase is an accepted marker of macrophage activation. In this study, we investigated serum chitotriosidase levels in pulmonary tuberculosis (PTB). METHODS: Forth-two patients with PTB and 30 healthy subjects were enrolled in the study. The radiological extent of PTB, radiological sequela after treatment, and the degree of smear positivity were assessed. Chitotriosidase levels were measured by a fluorometric method. RESULTS: The serum chitotriosidase levels of the PTB patients were significantly higher than those of the control subjects (39.73+/-24.97 vs. 9.63+/-4.55 nmol/mL/h, P<0.001). After completion of the standard 6-month antituberculous treatment, chitotriosidase levels in PTB patients significantly decreased (10.47+/-4.54 nmol/mL/h, P<0.001). Chitotriosidase levels correlated significantly with the radiological extent of PTB, degree of smear positivity, and post-treatment radiological sequela score (r=0.439, r=0.449, and r=0.337, respectively). CONCLUSIONS: This study demonstrated that serum chitotriosidase levels increase in PTB; therefore, chitotriosidase can be used as a marker of disease activity, severity, and response to treatment.
