Clinical application value of prognostic nutritional index for predicting survival in patients with advanced non-small cell lung cancer
10.3760/cma.j.issn.0253-3766.2017.02.015
- VernacularTitle: 预后营养指数评估中晚期非小细胞肺癌患者预后的临床应用价值
- Author:
Wenjuan XU
1
;
Yanmeng KANG
2
;
Ling ZHOU
2
;
Fangfang CHEN
2
;
Yinghua SONG
2
;
Caiqing ZHANG
2
Author Information
1. Taishan Medical University, Tai′an 271000, China
2. Department of Respiratory Medicine, Qianfoshan Hospital of Shandong Province, Shandong University, Jinan 250014, China
- Publication Type:Clinical Trail
- Keywords:
Carcinoma, non-small-cell lung;
Prognostic nutritional index;
Prognosis
- From:
Chinese Journal of Oncology
2017;39(2):146-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical application value of prognostic nutritional index(PNI) for predicting overall survival(OS) in patients with advanced non-small cell lung cancer (NSCLC).
Methods:123 patients with histologically confirmed non-small cell lung cancer were enrolled in this study, and their clinical and laboratory data were reviewed. The PNI was calculated as 10×serum albumin value+ 5×total lymphocyte countin peripheral blood.Univariate and multivariate analyses were used to identify the potential prognostic factors for advanced NSCLC.
Results:PNI of the 123 NSCLC patients was 46.24±6.56. PNI was significantly associated with age, weight loss and pleural effusion (P<0.05). However, it showed no relationship with sex, smoking, hemoptysis, chest pain, dyspnea, histological type, clinical stage, and administration of chemotherapy (P>0.05). The median OS of the 123 patients was 19.5 months. The median OS in the higher PNI group (PNI≥46.24) and lower PNI group(PNI<46.24) were 25.2 months and 16.4 months, respectively.The 1-year survival rates were 80.6% and 63.9%, and 2-year survival rates were 54.8% and 19.6%, respectively (P<0.01). Univariate analysis showed that PNI, age, dyspnea, and weight loss were related to the OS of the advanced NSCLC patients (P<0.05). Multivariate analysis identified PNI as an independent prognostic factor for OS of advanced NSCLC (P<0.001).
Conclusion:PNI can be easily calculated, and may be used as a relatively new prognostic indicator for advanced NSCLC in clinical practice.
