Research advances in the pathogenesis of non-alcoholic fatty liver disease-associated liver cancer
10.3760/cma.j.issn.1007-3418.2017.02.016
- VernacularTitle: 非酒精性脂肪性肝病相关肝癌发病机制的研究进展
- Author:
Wei HUANG
1
;
Xinxin ZHANG
Author Information
1. Department of Infectious Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
- Publication Type:Review
- Keywords:
Carcinoma, hepatocellular;
Non-alcoholic fatty liver disease;
Non-alcoholic steatohepatitis
- From:
Chinese Journal of Hepatology
2017;25(2):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty fiver disease (NAFLD) is one of the most common causes of chronic liver disease in clinical practice. It develops from simple fatty liver, nonalcoholic fatty hepatitis to liver fibrosis which may develop liver cirrhosis and result in hepatocellular carcinoma(HCC) eventually. Although studies show that many cell signaling pathways, genes and cell factors are involved in the progression and development of NAFLD related HCC, the exact mechanism underling the pathogenesis of NAFLD-HCC remains poorly understand. Here in this review, we give a summary of the recent findings at home and abroad that describe the epidemiology and pathogenesis of NAFLD associated HCC.
