Expression of long non-coding RNA SNHG8 in Epstein-Barr virus-related gastric cancer and clinical outcome
10.3760/cma.j.issn.0529-5807.2017.02.004
- VernacularTitle: 长链非编码RNA SNHG8在EB病毒相关胃癌中的表达及其临床意义
- Author:
Baozhen CHEN
1
;
Xiandong LIN
;
Gang CHEN
;
Dan HU
;
Qiong ZHU
;
Yi SHI
;
Xiaojiang WANG
;
Shanfeng JIN
;
Hongfei WANG
;
Xiongwei ZHENG
Author Information
1. Department of Molecular Pathology, Fujian Provincial Cancer Hospital, Fuzhou 350014, China
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Herpesvirus 4, human;
Long-non-coding RNA
- From:
Chinese Journal of Pathology
2017;46(2):84-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of long non-coding RNA (lncRNA) SNHG8 in EB virus related gastric cancer and their correlation prognosis.
Methods:The expression of SNHG8 in 93 gastric cancers and 93 cancer-free controls, matched by age and sex, were determined by real-time PCR. EB virus expression was detected by EBER in situ hybridization.
Results:Forty-one gastric cancers were EB virus associated. For all gastric cancers, SNHG8 expression was 14 times higher (P=0.001) than that in non-cancer controls; in the EB virus related gastric cancers, SNHG8 expression was increased 25 times (P<0.05) over EB virus negative gastric cancers. SNHG8 expression level was also significantly associated with TNM staging (P<0.05).
Conclusions:SNHG8 may act as a proto-oncogene, participating in gastric carcinogenesis.EB virus infection of gastric mucosa may promote SNHG8 expression.
