The research of rBCG inhibiting function on EB virus positive tumors
10.3760/cma.j.issn.1003-9279.2017.02.001
- VernacularTitle: 重组卡介苗对EB病毒阳性肿瘤的抑制作用研究
- Author:
Qingjie XUE
1
,
2
;
Yunqin LI
1
;
Chunqing YANG
2
;
Yuanyuan YANG
1
;
Ting CHEN
1
;
Shigen LI
1
Author Information
1. Department of Pathogenic Biology, Jining Medial University, Jining 272067, China
2. Institute of Neuroscience, Jining Medial University, Jining 272067, China
- Publication Type:Journal Article
- Keywords:
rBCG;
Anti-tumor;
EB virus
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(2):89-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The inhibition function on EB virus positive tumors with rBCG (recombinant BCG) was researched.
Methods:After cancer models of EB virus positive tumor cells(GT39)were established in C57BL/6 mice, the mice survival conditions, tumor weight and tumor formation time were analyzed, flow cytometry was used to research the proliferation of CD4+ T. Inhibition of rBCG to cancer was researched, HE staining of the mice tumor tissue was used to detect and analyze lymphocyte infiltration. Single factor analysis method of variance (One-way ANOVA) was processed for rBCG′s inhibition evaluation by SPSS 11.0 statistical software.
Results:Compared with the control group, rBCG group significantly slowed tumor growth, tumor formation time was delayed, rBCG significantly prolonged survival time of the mice.
Conclusions:rBCG had inhibition to EB virus positive tumors in mice.
