Clinical experience of 302 cases with brain abscess
10.3760/cma.j.issn.0529-5815.2017.02.015
- VernacularTitle: 脑脓肿302例临床治疗经验总结
- Author:
Xiaopeng CUI
1
;
Xinwang CAI
;
Zhen ZHANG
;
Nannan GAO
;
Pengran LIU
;
Jia LI
;
Shuyuan YANG
;
Jianning ZHANG
;
Xinyu YANG
Author Information
1. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
- Publication Type:Journal Article
- Keywords:
Brain abscess;
Mortality;
Treatment
- From:
Chinese Journal of Surgery
2017;55(2):151-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the diagnosis and treatment experience of brain abscesses and improve prognosis.
Methods:The data of 302 patients of brain abscess at Department of Neurosurgery in Tianjin Medical University General Hospital from 1980 to 2014 was analyzed retrospectively. There were 215 male and 87 female patients aged from 11 to 82 years with mean age of (30±8) years. The patients was divided into 1980-2001 group and 2002-2014 group according to different diagnosis and the treatment methods. The therapy methods include operation and conservative treatment. There were 196 cases received operation, including 95 cases of excision, 89 cases of ventriculopuncture, 12 cases of excision after ventriculopuncture, 106 cases received drug conservative therapy. Two groups of information including clinical manifestation, abscess location, therapeutic effect and prognosis were compared by χ2 test.
Results:Compared to 1980-2001 group, adjacent infection incidence declined(χ2=8.000, P=0.005). The ratio of single abscess declined and multiple abscess increased(χ2=11.060, P=0.001), the infection proportion of frontal lobe and temporal lobe decreased(χ2=9.080, P=0.003; χ2=15.440, P=0.000). The ratio of headache and vomit and papilledema declined significantly(χ2=23.290, P=0.000; χ2=21.020, P=0.000; χ2=2.290, P=0.001). Total mortality of 302 patients were 23 cases and 5 cases of 1980-2001 group and 2002-2014 group (10.4% vs. 6.3%, χ2=1.180, P=0.277). However, there were statistical difference in postoperative mortality between both groups (14.4% vs. 4.0%, χ2 =3.880, P=0.049).
Conclusion:With the application of antibiotics and the development of neurosurgical techniques, the prognosis of brain abscess has been improved.
