Multi-gene assay profiling testing and individualized therapy in breast cancer
10.3760/cma.j.issn.0529-5815.2017.02.005
- VernacularTitle: 乳腺癌多基因阵列表达谱检测与个体化治疗
- Author:
Xiaosong CHEN
1
;
Kunwei SHEN
Author Information
1. Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Gene testing;
Molecular typing
- From:
Chinese Journal of Surgery
2017;55(2):99-103
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is a heterogenetic disease. Multi-gene assay profiling can classify breast cancer into several molecular subtypes, which is better to predict disease prognosis and treatment response. Two prospective clinical trials validated the prognosis predictive value of 21 gene recurrence score and MammaPrint in early breast cancer, than to decrease the prescription of adjuvant chemotherapy and avoid side effect of chemotherapy. New multi-gene assay profiling integrating clinic-pathological factors or reflecting disease development and metastasis can help us predict disease outcome better, thus to achieve individualized therapy in breast cancer.
