Hereditary Colon Cancer: Lynch Syndrome.
- Author:
Eunjeong JANG
1
;
Daniel C CHUNG
Author Information
1. Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA. dchung@partners.org
- Publication Type:Review
- Keywords:
Lynch syndrome;
Mismatch repair gene;
Microsatellite instability;
Immunohistochemistry;
Hereditary nonpolyposis colon cancer;
Colon cancer
- MeSH:
Colon;
Colonic Neoplasms;
Colorectal Neoplasms;
Colorectal Neoplasms, Hereditary Nonpolyposis;
Counseling;
DNA Mismatch Repair;
Germ-Line Mutation;
Humans;
Immunohistochemistry;
Mass Screening;
Microsatellite Instability;
Molecular Biology
- From:Gut and Liver
2010;4(2):151-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is one important way to identify at-risk individuals. The elucidation of the molecular genetics of this syndrome has made it possible to screen for the disorder with molecular tests. Microsatellite instability and/or immunohistochemistry followed by germline testing for mutations in MMR genes is now a standard approach for clinically suspected cases. Correctly recognizing Lynch syndrome is essential for the application of appropriate screening and surveillance measures. Close surveillance and risk-reducing operations can decrease cancer-related mortality. In addition, counseling is an important component of the management of any family with Lynch syndrome.
