Effect of the mediation of the taurine on striatum tissue Ca2+ homeostasis in manganese exposed rats
10.3760/cma.j.issn.1001-9391.2017.02.003
- VernacularTitle: 牛磺酸对锰染毒大鼠纹状体神经组织细胞钙平衡调节的影响
- Author:
Songlin WU
1
;
Xuan QIN
;
Songchao GUO
Author Information
1. Department of Phylaxiology, Xiamen Medical College, Xiamen 361023, China
- Publication Type:Journal Article
- Keywords:
Manganese;
Taurine;
Corpus striatum;
Ca2+ homeostasis;
Rats
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(2):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To elucidate the effect of taurine on neurotoxicity induced by Mn by investigating activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase and content of Mn and active calmodulin in manganese exposed rats.
Methods:156 male SD rats were randomly divided into 1 control group, 3 manganese exposed groups (10, 15, and 20 mg/kg respectively) , and 9 taurine intervened groups based on orthogonal design (doses of taurine intervention were 100, 150, and 200 mg/kg respectively) , with 12 rats in each group. After 12 weeks of exposure, all rats were decapitated and corpus striatums were removed, activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase and content of Mn and active calmodulin were analyzed.
Results:The corpus striatum Mn content of the 3 dose groups exposed to Mn and 9 taurine intervened groups were significantly higher than that of the control group (P<0.05) . Active calmodulin content in 10 mg/kg manganese exposed group was significantly higher than that of the control group (P<0.05) . 150 and 200 mg/kg of taurine could decrease active calmodulin content of the group exposed to 10 mg/kg of Mn (P<0.05) . The corpus striatum activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase of the 3 dose groups exposed to Mn were significantly lower than that of the control group (P<0.05) . 150 mg/kg of taurine could increase activities of Na+-K+-ATPase of the group exposed to 10 mg/kg of Mn (P<0.05) . 150 and 200 mg/kg of taurine could respectively improve activities of Ca2+-Mg2+-ATPase of the group exposed to 15, 10 mg/kg of Mn (P<0.05) .
Conclusion:Mn can decrease the rats corpus striatum activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase, effect level of active calmodulin in relation to dose of Mn, to a certain extent, taurine could regulate activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase and improve the level of active calmodulin.
