Association between variations in protocadherin 15 gene and occupational noise-induced hearing loss
10.3760/cma.j.issn.0253-9624.2017.01.006
- VernacularTitle: 原钙黏蛋白15基因多态性与职业人群噪声性听力损失易感性的关系分析
- Author:
Xiangrong XU
1
;
Qiuyue YANG
;
Jie JIAO
;
Yuxin ZHENG
;
Lihua HE
;
Shanfa YU
;
Guizhen GU
;
Guoshun CHEN
;
Wenhui ZHOU
;
Hui WU
;
Yanhong LI
;
Huanling ZHANG
;
Zengrui ZHANG
Author Information
1. Department of Occupational and Environmental Health, School of Public Health, Peking University, Beijing 100191, China
- Publication Type:Journal Article
- Keywords:
Noise, occupational;
Case-control studies;
Noise-induced hearing loss;
Genetic variability;
PCDH15
- From:
Chinese Journal of Preventive Medicine
2017;51(1):20-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The aim of this study was to investigate whether genetic variability in the protocadherin 15 (PCDH15) gene may correspond with increased susceptibility to noise-induced hearing loss (NIHL) in a Chinese population.
Methods:A nested case-control study was performed that followed a cohort of 7 445 noise-exposed workers in a steel factory of Henan province in China from January 1, 2006 to December 31, 2015. In this study, 394 cases who had an average hearing threshold of more than 40 dB (A) in high frequency were defined as the case group, and 721 controls who had an average hearing threshold of less than 35 dB (A) in high frequency and less than 25 dB (A) in speech frequency were defined as the control group. A questionnaire was completed by participants and a physical test was also conducted. SNP genotyping was performed using the SNPscanTM Kit. Multivariate unconditional logistic regression additive models were used to analyze the genotypes in different groups, and the association with NIHL. Unconditional logistic regression models were used to assess the associations between the genotypes and NIHL.
Results:The average age of study participants was (40.5±8.3) years and the median number of noise-exposed working years M (P25, P75) was 21.1 (9.1, 27.3). The range of noise exposed levels and the levels of cumulative noise exposure (CNE) were 80.1- 98.8 dB(A) and 86.6- 111.2 dB(A), respectively. Only the distribution of the genotypes (TT/CC/CT) of rs11004085 in the PCDH15 gene showed a significant difference between the case and control groups (P=0.049). In the case group, the distribution was 370 (93.9%), 24 (6.1%) and 0; in the control group, the distribution was 694 (96.3%), 23 (3.2%) and 1 (0.1% ). After smoking, drinking, hypertension, height and CNE adjustment, compared with the TT genotype individuals with the CC/CT genotype had a 1.90-fold increased risk of NIHL (95% CI: 1.06- 3.40). After stratified these data by the noise exposure level or CNE when the noise exposure level was>85 dB (A), compared with cases with the AA genotype of rs10825113, individuals with the GA/GG genotype had a 2.63-fold increased risk of NIHL (95% CI: 1.12- 6.14). When the CNE was ≤ 98 dB(A), compared with cases with the TT genotype of rs11004085, individuals with the CC/CT genotype had a 2.96-fold increased risk of NIHL (95% CI: 1.33- 6.56). However, these differences were not significant after Bonferroni correction had been applied.
Conclusions:The results confirmed that genetic variation within the PCDH15 gene may affect the susceptibility to NIHL.
