Comparison of age-based clinical and abnormal immune parameters in patients with Henoch-Schönlein purpura
10.3760/cma.j.issn.0253-2727.2017.01.013
- VernacularTitle: 不同年龄亨-舒综合征患者临床与免疫学特征研究
- Author:
Na ZHANG
;
Peijing GUO
;
Pinli LIU
;
Hongrong YANG
;
Jing XIAO
;
Xinpeng LI
;
Jinbo HUANG
;
Yizhou ZHENG
1
Author Information
1. Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China
- Publication Type:Journal Article
- Keywords:
Purpura, Schoenlein-Henoch;
Lymphocyte subset;
Immunoglobulin;
Complement C3;
Complement C4
- From:
Chinese Journal of Hematology
2017;38(1):60-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore age-based clinical and immune parameters in Henoch-Schönlein purpura (HSP) to determine clinically useful markers reflecting disease characteristic.
Methods:A cohort of 502 patients with HSP were enrolled into this retrospective study to evaluate their clinical and immune data.
Results:Majority HSP cases occurred at age ≤14 years and showed significant immune imbalances of ESR, CD3+ cells, CD4+ cells, CD3-CD16+CD56+ cells, CD4+/CD8+ cells, IgG, IgA, IgM, IgE, complements C3/C4 and ASO in the acute phase. Compared to patients aged >14 years, symptoms of joint were more frequent at disease onset in patients aged ≤14 years (20.8% vs 7.6%, χ2=13.547, P<0.001) , and involvement of digestive tract and joint were also more frequent (57.4% vs 33.8%, χ2=24.106, P<0.001; 55.9% vs 32.5%, χ2=23.768, P<0.001, respectively) , but not for involvement of kidney (21.4% vs 51.3%, χ2=42.440, P<0.001) . The patients aged ≤14 years had distinct immune state, reductions of CD3+ cells, CD4+ cells and IgG were more frequent than patients aged >14 years, also increase of ASO (33.1% vs 20.0%, χ2=6.656, P=0.010) , but not increase of IgA (2.6% vs 39.4%, χ2=15.582, P<0.001) . In addition, reduction of IgG and increase of IgE were positively associated with digestive tract involvement (P<0.001, P=0.001, respectively) , reduction of CD3+CD4+ cells and normal IgM were positively associated with joint involvement (P=0.004, P=0.003, respectively) , increase of CD3+CD8+ cells and normal CD3+ cells were positively associated with kidney involvement (P=0.032, P=0.014, respectively) .
Conclusion:HSP showed significant immune imbalance in the acute phase, patients between aged ≤14 and >14 years had distinct clinical and immune characteristic, and abnormal immune parameters were significantly associated with organ involvements.
