Clinicopathologic features of mammary analogue secretory carcinoma of salivary glands
10.3760/cma.j.issn.0529-5807.2017.01.008
- VernacularTitle: 涎腺乳腺样分泌癌的临床病理分析
- Author:
Xueping ZHANG
1
;
Hao NI
;
Xuan WANG
;
Hui CHEN
;
Shanshan SHI
;
Bo YU
;
Xiaojun ZHOU
;
Qiu RAO
Author Information
1. Department of Pathology, Medicine School of Nanjing University/Nanjing Jinling Hospital, Nanjing 210002, China
- Publication Type:Journal Article
- Keywords:
Salivary gland neoplasms;
SOX transcription factors;
S100 proteins;
Pro-oncogene proteins c-kit;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2017;46(1):34-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features of mammary analogue secretory carcinoma (MASC) of salivary glands, and its diagnosis, differential diagnosis, immunohistochemistry and molecular pathology.
Methods:Seventeen cases of MASC were enrolled, with 9 cases of salivary acinar cell carcinoma and 18 cases of adenoid cystic carcinoma as control groups from Nanjing General Hospital from 1997 to 2014 were included in this retrospective study, combined with immunohistochemistry and molecular detection of ETV6-NTRK3 gene fusion. All cases were histologically reviewed with immunohistochemical staining (EnVision) for S-100 protein, SOX10, GATA3, CD117 expression in each group. Fluorescence in situ hybridization (FISH) was used to detect the ETV6-NTRK3 gene fusion.
Results:The age of MASC patients ranged from 27 to 74 years with mean age of 47 and ratio of male and female was 4∶3. All cases showed infiltrative growth and diverse cytology and histology, including lobular (8 cases), cystic papillary (3 cases), cribriform mixed with papillary and glandular structures (6 cases) at various proportions. Some tumors of MASC also exhibited solid growth areas with occasional microcystic honeycombed pattern composed of small cysts merged into larger cysts resembling thyroid follicles. S-100 protein and SOX10 were strongly positive in all MASC cases (17/17). In addition, there was insignificant positivity for GATA3 (3/17) and CD117 (4/17). ETV6 gene fusion detection was informative in 12 MASC cases by FISH with 10 positive cases and 2 negative cases.
Conclusions:Combined immunohistochemical positivity of S-100 protein, CD117 and SOX10 are useful in the diagnosis and differential diagnosis of MASC. FISH detection of ETV6-NTRK3 fusion offers an additional molecular diagnostic marker for the diagnosis.
