The roll of innate immunity in the pathogenesis and treatment of HBV infection
10.3760/cma.j.issn.1003-9279.2017.01.018
- VernacularTitle: 固有免疫在HBV感染发病和治疗中的作用
- Author:
Xiaojing QU
1
;
Lu ZHANG
;
Minghui LI
;
Yao XIE
Author Information
1. Second Division of Liver Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding, Beijing 100015, China
- Publication Type:Review
- Keywords:
Hepatitis B virus;
Host;
Innate immunity;
Immunosuppression
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(1):83-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The pathogenesis of HBV infection is the result of a complex interactions between the host immune system and the virus, the host immune system involves innate immune and adaptive immune. Now, it is thought that host immune responses to viral particles and proteins are important factors that determine whether HBV is cleared or persists and hepatocytes injured. Innate immune system is the first defending line of host against viral infection. However, many studies have shown that HBV can develop tactics to escape innate immune recognition and interfere with innate immune signaling pathways and induce immunosuppression. It is necessary to analysis the functions and status of host innate immunity in HBV infection which may contribute to find novel approaches to eliminate HBV. This review will present the current understanding of innate immune components including pattern-recognition receptors(PRRs)、dendritic cells(DCs)、natural killer(NK)/natural killer T(NKT)cells、T regulatory cells(Tregs) and interferons(IFNs).
