Research progress of murine norovirus infection and immunity
10.3760/cma.j.issn.1003-9279.2017.01.017
- VernacularTitle: 鼠诺如病毒感染免疫研究进展
- Author:
Huimin WANG
1
;
Lili PANG
2
;
Yan XIN
1
;
Zhaojun DUAN
2
Author Information
1. Department of Immunology, Basic School of Medical Science, Inner Mongolia Medical University, Hohhot 010110, China
2. Key Labortory of Medical Virology, Ministry of Health National Institute for Viral Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing 102206, China
- Publication Type:Review
- Keywords:
Murine norovirus;
Infection;
Immune response
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(1):79-82
- CountryChina
- Language:Chinese
-
Abstract:
Human norovirus (NoV) is a member of the calicivirus family, can cause nausea, vomiting, abdominal pain and diarrhea as the main clinical symptoms of acute gastroenteritis. Human norovirus infection can be popular in the world, all ages, causing serious burden of disease. Due to the lack of suitable small animal models, there is still a lack of understanding of human immune to norovirus infection and pathogenesis. Murine norovirus (MNV) was originally isolated in immune deficient mice, and causes infection and epidemic in mice. MNV provides an alternative model to study human norovirus infection and the host intestinal immune mechanism. This article will elaborate on two aspects of innate immunity and adaptive immunity.
