The clinical diagnosis value and significance of serum sH2a level on early hepatic fibrosis degree
10.3760/cma.j.issn.1003-9279.2017.01.012
- VernacularTitle: 外周血可溶性sH2a在早期诊断肝纤维化程度中的价值
- Author:
Lei WANG
1
;
Peihua JIN
1
;
Huanjia QU
2
;
Yanming JIANG
3
;
Jie WANG
3
;
Ling GONG
3
;
Gongying CHEN
3
;
Mengfei ZHU
3
;
Junping SHI
3
Author Information
1. Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China
2. Hangzhou Normal University, Hangzhou 310053, China
3. The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310053, China
- Publication Type:Journal Article
- Keywords:
hepatitis cirrhosis;
sH2a;
serum level;
liver tissue pathology
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(1):57-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective:We aimed, in our prospective study, to assess the predictive value of serum non-invasive and biochemical markers for clinical diagnosis of significant fibrosis (including early stages).
Methods:We measured sH2a levels in serum, comparing with routine liver function markers. We compared blindly pretreatment serum samples from a cohort of hepatitis B patients without non-alcoholic fatty liver disease(NAFLD), which had histological grades of liver fibrosis, with NAFLD individuals and CHB with NAFLD patients. Statistical analysis was by Student′s t test, and receiver-operating characteristic (ROC) curves were drawn.
Results:ROC curves showed that serum sH2a had greater diagnostic performance than routine liver function markers compared with histological grades of liver fibrosis(S0, S1-2, S3-4). ROC curves showed that using a sH2a cut-off point of 0.79 was with highest sensitivity as 63% and highest specificity as 80%. And sensitivity as 96.7% and specificity as 75.5% when using a sH2a cut-off point of 0.77.
Conclusions:sH2a has the potential to be a uniquely sensitive and specific novel marker for liver fibrosis and function.
