Clinical effectiveness of salvianolic acid B and triamcinolone acetonide in treatment of oral submucous fibrosis
10.3760/cma.j.issn.1002-0098.2017.01.004
- VernacularTitle: 曲安奈德和丹参酮注射液治疗口腔黏膜下纤维化的效果评价
- Author:
Xinchun JIAN
1
;
Lian ZHENG
1
;
Rong ZHU
1
;
Binping WANG
2
;
Ting ZHOU
2
;
Yongxiu DU
2
Author Information
1. Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Institute of Oral Precancerous Lesions, Central South University, Changsha 410008, China
2. Department of Oral Mucous Disease, Stomatology Center, Affiliate Haikou Hospital of Central South University Xiangya Medical School & Hainan Provincial Stomatology Center, Haikou 570208, China
- Publication Type:Journal Article
- Keywords:
Oral submucous fibrosis;
Triamcinolone acetonide;
Injections, intralesional;
Salvianolic acid B
- From:
Chinese Journal of Stomatology
2017;52(1):16-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical effectiveness of salvianolic acid B (SA-B) and triamcinolone acetonide (TA) by means of combined intralesional injection in the treatment of oral submucous fibrosis (OSF).
Methods:According to clinical findings and symptoms, TA combined with SA-B were consecutively applied intralesionally 1 time weekly for 30 times. Mouth opening degree, color change of the buccal mucosae and numeral increase of the capillary vessels were determined by degree Ⅰ-Ⅳ visual analog scale were evaluated at 12, 24, and 36 months, respectively.
Results:One hundred and fourteen subjects fulfilled the study without obvious adverse reactions. After treatment for 1 year, the net gain in mouth opening of the early stage group was (5.5 ± 1.5) mm at 12 months, (8.8 ± 1.6) mm at 24 months and (12.0±1.2) mm at 36 months. The net gain in mouth opening of the middle stage group were (5.3±1.7) mm at 12 months, (10.5±1.5) mm at 24 months and (14.5±2.4) mm at 36 months. The net gain in mouth opening of the advanced stage group were (5.7±1.3) mm at 12 months, (13.7±1.3) mm at 24 months and (15.5±1.5) mm at 36 months. The effective rates of color change of the buccal mucosae and numeral increase of the capillary vessels after treatment for 36 months were 100% in early stage group, 93% (51/55) in middle stage group and 90% (36/40) in advanced stage group.
Conclusions:TA and SA-B combined intralesional injection in the treatment of oral submucous fibrosis is effective.
