A clinical study of serum protein markers in patients with 1-bromopropane poisoning
10.3760/cma.j.issn.1001-9391.2017.01.014
- VernacularTitle: 1-溴丙烷中毒患者血清蛋白标志物的临床研究
- Author:
Rongming MIAO
1
;
Bing CAO
;
Yongming YAO
;
Yingyi ZHANG
;
Weimin WU
;
Zhonghua FANG
;
Rui ZHAO
;
Cheng LUO
;
Baoli ZHU
Author Information
1. Wuxi NO.8 People's Hospital (Wuxi Hospital for Prevention and Treatment of Occupational Disease) , Wuxi 214011, China
- Publication Type:Case Reports
- Keywords:
1-Bromopropane;
Poisoning;
Protein
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes in protein expression in patients with 1-bromopropane (1-BP) poisoning using high-throughput proteomic technique and to screen out protein markers.
Methods:Serum samples were collected from 3 patients with 1-BP poisoning and 15 controls. The label-free proteomic tech-nique was used for the quantitation and identification of proteins expressed in these samples, and the results were compared between the patients with 1-BP poisoning and the control population. The bioinformatics tools were used to analyze the function of differentially expressed proteins.
Results:Compared with the control popula-tion, the patients with 1-BP poisoning had >2-fold upregulation of 38 proteins and >2-fold downregulation of 68 proteins. The differentially expressed proteins were mainly involved in immune response, signal transduction, and stress response.
Conclusion:The proteins screened out may be potential protein markers for 1-BP poison-ing, which provides reliable and precise methods and thoughts for the diagnosis of 1-BP poisoning.
