Clinical effect of combined artificial extracorporeal liver support therapy for toxic hepatic failure
10.3760/cma.j.issn.1001-9391.2017.01.013
- VernacularTitle: 组合型人工肝技术治疗中毒性肝功能衰竭的临床研究
- Author:
Yadong ZHOU
1
,
2
;
Lin YANG
;
Qiufeng HAN
;
Qingbin TANG
;
Yuelei CHENG
;
Jixue SHI
Author Information
1. Affiliated hospital of Taishan Medical University
2. Taian 271000, China
- Publication Type:Case Reports
- Keywords:
Live, artificial;
Poison;
Liver failure
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(1):51-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of plasma exchange (PE) versus double plasma molecular adsorption system combined with PE (DPMAS+PE) in the treatment of toxic hepatic failure.
Methods:A total of 67 patients with toxic hepatic failure who were admitted during the same period of time were divided into PE group, DPMAS+ PE group, and control group. The 22 patients in the PE group were treated with PE alone, and the 24 patients in the DPMAS+PE group were given DPMAS combined with PE. The clinical out-come was compared between the three groups.
Results:Both treatment groups had significantly higher clinical response rate and 24-week survival rate than the control group. After treatment, both treatment groups had significant reductions in the serum levels of total bilirubin (TBil) , direct bilirubin (DBil) , alanine aminotransfer-ase (ALT) , and aspartate aminotransferase (AST) , and the PE group had significant reductions in the albumin (Alb) level and activated partial thromboplastin time (APTT) (P<0.05) ; the DPMAS+PE group showed no sig-nificant changes in the Alb level and APTT (P>0.05). There were no significant differences in TBil, DBil, ALT, and AST between the two treatment groups after treatment (P>0.05). After treatment, the PE group had significantly higher Alb level and APTT than the DPMAS + PE group (P<0.05). Compared with the control group, both treatment groups had significant reductions in TBil, DBil, ALT and AST after treatment (P<0.05).
Conclusion:The two artificial liver support techniques can significantly improve patients' liver function and in-crease their survival rate, and the combined artificial liver support technique can reduce the amount of plasma used.
