Clinical abservations of pulmonary surfactant' s autologous transfusion in massive lung lavage
10.3760/cma.j.issn.1001-9391.2017.01.003
- VernacularTitle: 大容量肺灌洗中肺泡表面活性物质自体回输临床观察
- Author:
Xinyu XIAO
1
;
Xiaoping ZHANG
;
Gang CHEN
;
Yang YUAN
;
Guoxuan MA
;
Jianyong DUAN
;
Zhiqian SUN
;
Jinghui HUANG
;
Xing CAO
;
Jin ZHANG
Author Information
1. Institute of Occupational Disease Prevention and Treatment, Beidaihe, State Administration of Work Safety, Qinhuangdao 066104, China
- Publication Type:Journal Article
- Keywords:
Pneumoconiosis;
Bronchoalveolar lavage;
Pulmonary surfactant;
Respiratory function tests
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Investigate the pulmonary surfactant autotransfusion effect on the recovery of respiratory function in patients with whole lung lavage, to provide theoretical basis for the clinical application.
Methods:We taken 30 patients of pneumoconiosis treated by whole lung lavage as the subjects. We extracted the pulmonary surfactant from lavage fluid, after single postoperative lung lavage for the first time; after one weeks when the second times of lung lavage were performed to the other side of the lung of patients, we put PS into the right side. We taken the patients the second times of lung lavage who were put PS into the right side as returning group, the first times of lung lavage who were not put PS into as on returning group. We observed indi-cators, such as expiratory resistance, respiratory work, lung compliance, airway pressure, PO2, the pulmonary function recovery time and other indicators, comparing with the changes of pulmonary function before lung la-vage for the first time and at 0、60、90、120 min after the pulmonary surfactant autotransfusion.
Results:Com-pared with the no returning group, the expiratory resistance of the returning group decreased significantly at 90 min、120 min after the pulmonary surfactant autotransfusion; the respiratory work and airway pressure of the re-turning group decreased significantly at 60、90、120 min after the pulmonary surfactant autotransfusion, there was statistically significant in the difference between different groups (P<0.05, P<0.01). Compared with the no returning group, the lung compliance and the PO2 of the returning group increased significantly at 60 min、90 min、120 min after the pulmonary surfactant autotransfusion, there was statistically significant in the difference between different groups (P<0.05, P<0.01). The lung function recovery time of returning group was (155.7 ± 35.2) min, the lung function recovery time of no returning group was (183.71±41.81) min, there was statistical-ly significant in the difference between different groups (P<0.05). Compared with the no returning, there were not statistically significant in the difference of the Heart rate、the systolic blood pressure and the diastolic blood pressure about the returning at 60、90、120 min after the pulmonary surfactant autotransfusion.There was no ad-verse reactions such as pulmonary infection, pulmonary infection and so on.
Conclusion:The pulmonary surfac-tant autotransfusion may reduce expiratory resistance, work of breathing, airway pressure; improve lung compliance, alveolar ventilation function; increase oxygen partial pressure and decrease the surgery recovery time in patients with pneumoconiosis.
