Novel nano-scaled Mn-metal-organic framework for enhancing photodynamic therapy through overcoming tumor hypoxia
10.11665/j.issn.1000-5048.20190607
- VernacularTitle:一种新型锰金属有机框架纳米载体用于克服肿瘤缺氧增效光动力治疗
- Author:
Huayuan CUI
1
;
Dan YAO
;
Yuxiang WANG
;
Yiqiao HU
Author Information
1. 南京大学生命科学学院
- Publication Type:Journal Article
- Keywords:
Mn-metal-organic framework;
porphyrin;
photodynamic therapy;
oxygen;
antitumor
- From:
Journal of China Pharmaceutical University
2019;50(6):678-685
- CountryChina
- Language:Chinese
-
Abstract:
A Mn-clusters-porphyrin metal-organic framework nanosheet(nMn-MOF)was synthesized by coordination chelation to enhance photodynamic therapy. The nanosheet was characterized by dynamic light scattering, transmission electron microscopy and X-ray photoelectron spectroscopy. Oxygen sensor and ICG were used to investigate the production of oxygen and the singlet oxygen(1O2)generation. The cytotoxicity of the nanosheet against tumor cells were detected by CCK-8 assay, and the anti-hypoxia and oxygen-generation ability of nanosheets were investigated by fluorescence staining assay. The results indicated that this nanosheet could catalyze the intracellular H2O2 into O2, which overcame the tumor hypoxia. Furthermore, the generated oxygen was converted to cytotoxic 1O2 under the near infrared light irradiation, thereby enhancing photodynamic therapy.
