Advances in drug-induced gastrointestinal bleeding and its pathological mechanism
10.11665/j.issn.1000-5048.20190604
- VernacularTitle:药源性胃肠道出血及其病理机制的研究进展
- Author:
Han XU
1
;
Yuanyuan ZHANG
;
Junping KOU
Author Information
1. 中国药科大学中药学院中药药理与中医药系；江苏省中药评价与转化重点实验室
- Publication Type:Journal Article
- Keywords:
gastrointestinal bleeding;
mechanism;
signaling pathway;
advances
- From:
Journal of China Pharmaceutical University
2019;50(6):659-665
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced gastrointestinal bleeding is caused by drugs acting on the gastrointestinal tract, which damages the gastrointestinal mucosa causing erosion and ulceration. Many drugs can cause gastrointestinal bleeding including non-steroidal anti-inflammatory drugs, antithrombotic drugs, chemotherapy drugs, and antibacterial drugs, drugs induced gastrointestinal bleeding by destroying gastrointestinal mucosal barrier, inhibiting of angiogenesis, destroying coagulation mechanism and there are still few prevention methods. This study focused on the clinical research and mechanism of drugs. The research in recent 5 years were reviewed to illustrate drug-induced gastrointestinal bleeding, so as to illustrate the characteristic actions of drug and provide some references and clues for the prevention of drug-induced gastrointestinal bleeding.
